"What does stress have to do with autoimmune disease? or vitamin D?
You want me to take a bath?
Are you kidding me?"
The body needs vitamin D and magnesium in order to protect against allergic sensitivity within the immune system. Some types of immune cells can be made to be more or less “tolerant” of foreign protein - such as the DNA of an expectant infant, which is “foreign” to its mother’s DNA. The baby has half the DNA from the father too.
Some conditions, such as chronic stress, can make it difficult for the intestines to absorb magnesium which include having an excess amount of vitamin D. Excess vitamin D can lead to an over absorption of calcium in the intestines and an increased retention of the mineral by the kidneys, while at the same time less magnesium is absorbed and more is lost by the kidneys. A bath or foot soak with magnesium sulfate salt can bypass the intestinal problem of poor absorption and help provide what the kidneys need. Epsom salt is a well known brand of magnesium sulfate salt, about one cup to a half bath of water, soak for twenty minutes one to three times per week for better health and mood. It may help patients with autism or Bipolar Disorder Type 1 to have better mood stability. (G.1, G.2) Magnesium chloride is another form that can be used for topical skin absorption as concentrated drops or in a bath. (G.3)
The sulfate portion of the Epsom salt may be beneficial in addition to the magnesium for people with some types of conditions such as autism and may be more protective in a food environment that contains the herbicide glyphosate as a contaminant. It may interfere with the type of CYP enzyme (CYP enzymes are a large group important in many areas of the body: (G.4), more on this topic later) that is needed for the body to be able to use the sunshine method to make biologically active forms of vitamin D or of sulfate. The Epsom salt bath would provide the sulfate through skin absorption which would bypass the enzyme needed for the metabolic pathway that requires sunshine.
Too much can be a health risk as well as too little, because magnesium is electrically active and can cause the heart rate to slow down. Adequate vitamin D for mothers-to-be can help protect baby and mom from allergic immune reactions which may increase risk of autoimmune disease later in life. Magnesium is also important during pregnancy and lactation. Adequate intake might help relieve muscle cramps, a common discomfort of pregnancy. Other symptoms might include constipation, irritable mood or headaches, and ringing in the ears can be a more severe symptom.
CYP enzymes are involved in digestion and in the metabolism of many drugs including the opioids. If glyphosate is inhibiting the group then it may be part of the reason for the increased number of opioid overdose deaths. With less ability to breakdown the medication any dose that is consumed would remain in the body longer and might reach a deadly dose in a more petite woman or man. People with chronic kidney or liver disease are also at greater risk for inadequate breakdown of opioid and morphine drugs. (G.5)
Coffee lovers can rejoice, cafestol, a phytonutrient found in coffee helps promote the CYP enzyme involved in breaking down opioids. While grapefruit juice contains a phytochemical that can inhibit the enzyme:
- “Administration of CYP3A4 substrates or inhibitors can increase opioid concentrations, thereby prolonging and intensifying analgesic effects and adverse opioid effects, such as respiratory depression. Administration of CYP3A4 inducers can reduce analgesic efficacy.10,11,16 In addition to drugs that interact with CYP3A4, bergamottin (found in grapefruit juice) is a strong inhibitor of CYP3A4,26 and cafestol (found in unfiltered coffee) is an inducer of the enzyme.27” (G.5)
Coffee in quantity, (> 6 cups/day), such as “a pot a day” has been associated with prenatal issues. However one or two small servings of a caffeinated beverage during pregnancy is likely to be safe. (G.28) The standard recommendation used to be “none” and so many people may be familiar with that advice, however research has found coffee and caffeine to be safer than was feared. I like to know and provide the upper and lower ranges of safety - the “too much” and the “probably okay for most people” range or tolerable limits. A small serving of grapefruit juice is likely safe for most people. It has been a well known “effective care” recommendation in dietetics for patients taking certain medications to avoid grapefruit juice or grapefruit.
Based on the article and the excerpt people with severe kidney or liver disease and who are taking opioid medications might be safer to avoid all use of grapefruit juice. (G.5) Coffee would not be advisable for someone with severe kidney disease though either.
Checking for drug and nutrient interactions is part of a thorough nutrition assessment as negative symptoms may often be due to underlying problems that are being caused by something happening as part of the daily routine. A thorough nutrition assessment is like a detective investigating a mystery, looking for clues to what might be disrupting normal function.